The product information for Sevoflurane still recommends fresh gas flows of 2L/min or more. I realise this is based on research with rats that lack an enzyme that humans have, but has this recommendation been revised down anywhere in the world yet?
I commonly run sevo at under 1L/min FGF. Where do I stand medicolegally if the patient gets a renal problem (from any cause)?
I routinely go down to 500 ml/min, sometimes lower. Have done for years. No-one has keeled over yet.
The recommendation is certainly responsible for making a lot more money for the manufacturer of sevoflurane.