Rocuronium - priming technique?

[jafo1964]

Our experience with intubation with 0.6mg/kg of rocuronium for intubation offers only acceptable intubation conditions at 60 secs. This is surely inferior to intubating conditions offered by suxamethonium in the same time frame.
Roc 0.9mg/kg offers excellent intubation conditions, but undesirably prolongs the duration of action to more than 50 minutes making it an almost long acting relaxant
I am wondering if priming with 1/10th the intubating dose (0.05mg/kg) of roc given 2-3 mins before the intubating dose will improve intubating conditions at 60 secs.
Wonder if there is any literature or references available
Thanks for the help

[frontier]

hi,
  priming definitely reduces the intubation onset time.for your delight i wanted to attatch the PUBMED file ,but couldn't succeed.just go through the pubmed article by GRIFFITH KE.,JOSHI GP,WHITMAN PF,GARG SA,deptt. of anaesthesiology & pain management,university of TEXAS,southwestern medical center at DALLAS,75235-9068,USA;I.J.CLIN ANAESH.1997;MAY9(3);204-7.even you will be surprised use of ephedrine before induction also reduces intubation onset time.with regards

[drmohank]

any experiences in rocuronium injection pain / withdrawal movements?

[jafo1964]

Pain on injection occurs but is not too frequent.
I think propofol causes more problems with pain
I am not convinced that Rocuronium is cardiostable upto 5x ED 95 (product insert)
At 3 xED95 you definitely see tachycardia