hi all,
Im new here.. Please welcome me..
Can anybody please help me with this one.. How effecttve is ultane abbot (http://drugdelivery.ca/s3873-s-ULTANE.aspx) as an anaesthetic ?
Clear colourless liquid, non-flammable
Mode of action: Mechanism of general anaesthesia remains unclear
Routes: Inhalation, via a calibrated vaporiser. Induction dose 5-8%, maintenance 0.5-3%
Effects:
Cardiovascular system: Causes a decrease in myocardial contractility and mean arterial pressure. Has little effect on the heart rate and does not sensitise the myocardium to circulating catecholamines. Does not cause 'coronary steal'
Respiratory system: Causes an increase in respiratory rate; minute volume remains unchanged. Decreased response to hypoxia and hypercapnia. Has a pleasant, non-irritant odour. Relaxes bronchial smooth muscle
Central nervous system: Principal effect is general anaesthesia; little analgesic effect. Decreases cerebral vascular resistance and cerebral metabolic rate. Increases intracranial pressure in a dose-related manner. Does not cause epileptiform EEG activity
Genitourinary system: Decreases renal blood flow
Toxicity: Trigger agent for malignant hyperthermia
Absorption: Coefficients - blood/gas: 0.6; oil/gas: 47; minimum alveolar concentration: 2.05
Sevoflurane is exceptionally insoluble in blood; alveolar concentration therefore reaches inspired concentration very rapidly, resulting in a rapid induction of anaesthesia
Distribution: Initially to areas of high blood flow (brain, heart, liver and kidney). Later to less well-perfused organs
Metabolism: By hepatic cytochrome P450IIEI to yield hexafluoroisopropanol, which is further conjugated to its glucoronide. 3% of the absorbed dose is metabolised
Excretion: Via the lungs, predominantly unchanged. Elimination is rapid due to its low solubility
Special points: Sevoflurane is unstable in the presence of moist soda lime, producing small amounts of a sevo-olefin called 'Compound A'. Potentiates action of depolarising and non-depolarising muscle relaxants to a greater extent than either halothane or enflurane
Yeah, it's pretty good ;D