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Author Topic: Kinase Inhibitors and GA  (Read 2422 times)

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Kinase Inhibitors and GA
« on: November 23, 2011, 01:19:46 AM »
Hi all

Have a 65 year old lady posted for fractional curettage and proceed
She is a case of CML, treated and now in remission and is currently on on IMATINIB MESYLATE ( Gleevec)

THe side effects of this drug is quite exhaustive
This pt has an Effort tolerance < 4 METS and is a diabetic with reasonable control

Her history related to coagulation, renal and hepatic function is largely insignificant

Surgery may last 30 mins
I am planning to slip in a LMA under Propofol and Fentanyl
and maintain her under Spontaneous Ventilation with Sevoflurane

Any advices on how to do it better
Any areas i need to focus on



  • Yogen Bhatt, Mumbai, India
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Re: Kinase Inhibitors and GA
« Reply #1 on: November 25, 2011, 01:38:19 PM »
Got a good one. Love these  challengers.
Since the case is too small, not much to worry about. But given a choice I would still use only Sevo with Gases, a touch of 30 mic Fent may be. Propofol, only if very apprehensive, in low dose, just about 30mg as a hypnotic, but not as a main inducing agent. May or may not insert an LMA depending upon the speed of the surgeon.
But, I am sure, you must have done the case by now. Do let the group know how you managed.
Have always respected your judgement.
« Last Edit: November 25, 2011, 01:40:21 PM by yogenbhatt1 »
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