Today I read an review article "Propofol infusion syndrome" (PIRS) of authors P.C.A. Kam and d. Cardone published on Anaesthesia Volume 62, Number 7, July 2007.
The authors recommended that a propofol infusion rate of greater than 4mg/kg/h for longer than 48h should be avoided because a number of serious adverse effects such as metabolic acidosis, cardiac asystole, myocardial failure, rhabdomyolysis, and death.
Therefore, I want to know what drugs should be replaced to Propofol to infusion for long- term in operating room and intensive care unit and how to use them.
Thanks for your help.